Side Effects, Cost, Uses, and More

* For more information about this side effect, see the “Side effect focus” section below.

Side effect focus

Learn more about some of the side effects Tagrisso may cause.

Skin rash

Some people may have a skin rash while taking Tagrisso. This was one of the most common side effects in the drug’s studies. This side effect is usually mild but can be severe in rare cases.

A skin rash may be itchy, bumpy, and appear red or discolored. It’s also common to have dry skin while taking Tagrisso, which can make itchiness worse.

What might help

To help manage this side effect, there are a few different over-the-counter options. A medicated cream or ointment, such as hydrocortisone, may help ease the symptoms of a skin rash from Tagrisso. An oral antihistamine, such as diphenhydramine (Benadryl) or cetirizine (Zyrtec), can help relieve itching.

In most cases, a rash is a mild side effect of Tagrisso and not an allergic reaction. But since allergic reactions and other skin reactions can become severe, it’s important to tell your doctor about a rash or other skin reactions right away.

Lung problems, such as pneumonitis

Serious lung problems are a rare but possible side effect of Tagrisso. Lung problems that have been reported include:

• pneumonitis, which is inflammation (swelling) in the lungs
• interstitial lung disease (ILD), which is formation of scar tissue in the lungs due to inflammation

Symptoms of these conditions may include:

• cough
• shortness of breath
• trouble breathing
• fever

In rare cases, these side effects have been fatal. If you have concerns about your risk of pneumonitis or ILD, talk with your doctor.

Tagrisso is used to treat certain type of lung cancer. Keep in mind that lung cancer already causes some of the same symptoms as pneumonitis or ILD. You’ll want to watch for any symptoms that become worse or feel different than usual.

What might help

Tell your doctor right away if you have symptoms of a lung problem. If your doctor determines that you have pneumonitis or ILD, they’ll have you stop taking Tagrisso. They’ll also prescribe treatment for your lung condition.

Cardiac side effects

Tagrisso treatment may lead to serious cardiac (heart) problems. These problems include congestive heart failure (CHF) and long QT syndrome.

In rare cases, heart problems from Tagrisso have been fatal. If you’re concerned about your risk of heart problems while taking Tagrisso, talk with your doctor.

With CHF, your heart can’t pump enough blood throughout your body. Symptoms can include:

• tiredness
• dizziness
• swelling, usually in your legs, ankles, or feet
• dry cough that may get worse during physical activity
• shortness of breath that worsens when you’re lying down

Long QT syndrome is a type of abnormal heart rhythm. Symptoms include:

• dizziness
• feeling like your heart is skipping a beat
• fainting

What might help

Before taking Tagrisso, talk with your doctor about any heart problems you’ve had. If your doctor determines that it’s safe for you to take Tagrisso, they’ll monitor you closely during your treatment.

Tell your doctor right away if you notice any symptoms of heart problems. If they diagnose you with a new or worsened heart problem, they’ll likely have you stop taking Tagrisso.

Allergic reaction

Some people may have an allergic reaction to Tagrisso. This side effect wasn’t reported in the drug’s studies, but it’s still possible.

Symptoms of a mild allergic reaction can include:

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing.

Call your doctor right away if you have an allergic reaction to Tagrisso. But if you think you’re having a medical emergency, call 911 or your local emergency number.